Changes in spinal cord architecture after bpi in the newborn

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F-Litz
Posts: 970
Joined: Fri May 26, 2006 6:53 pm
Injury Description, Date, extent, surgical intervention etc: LOBPI, LTBPI at age 6.5, Sensory Issues, CP, Diaphragm Weakness, Aspberger's
Location: Ambler, PA

Changes in spinal cord architecture after bpi in the newborn

Post by F-Litz »

Brain. 2004 Jul;127(Pt 7):1488-95. Epub 2004 Jun 2. Links
Changes in spinal cord architecture after brachial plexus injury in the newborn.
Korak KJ, Tam SL, Gordon T, Frey M, Aszmann OC.
Division of Plastic and Reconstructive Surgery, Department of Surgery, University Clinics of Vienna School of Medicine, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Obstetric brachial plexus palsy is a devastating birth injury. While many children recover spontaneously, 20-25% are left with a permanent impairment of the affected limb. So far, concepts of pathology and recovery have focused on the injury of the peripheral nerve. Proximal nerve injury at birth, however, leads to massive injury-induced motoneuron loss in corresponding motoneuron pools and therefore limits the extent of functional recovery. In the present study, the role of spinal cord plasticity after injury and recovery from obstetric brachial plexus lesions was investigated. A selective injury to spinal roots C5 and C6 was induced in newborn Sprague-Dawley rats, leading to motoneuron loss in corresponding motoneuron pools. Recovery of extremity function was evaluated with different behavioural paradigms. Permanent changes of adjacent motoneuron pools were quantitatively evaluated by retrograde tracing and functional muscle testing. We report that the adjacent C7 motoneuron contribution to biceps muscle innervation increased four-fold after upper trunk lesions in newborns, thus compensating for the injury-induced motoneuron loss. These results indicate that, in obstetric brachial plexus palsy, changes in spinal cord architecture are an integral part not only of primary pathology but also of the subsequent recovery process. While present treatment is directed towards the restoration of neural continuity, future treatment strategies must recognize and take advantage of CNS participation in the injury and recovery process. Copyright 2004 Guarantors of Brain

PMID: 15175226 [PubMed - indexed for MEDLINE]


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Lenni
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Joined: Sun Feb 17, 2002 12:55 am

Re: Changes in spinal cord architecture after bpi in the newborn

Post by Lenni »

Thank you for sharing this Francine.

Please tell Maia hello from Ashley.

Lenni
Tanner's Mom
Posts: 288
Joined: Sun Oct 03, 2004 12:29 pm

Re: Changes in spinal cord architecture after bpi in the newborn

Post by Tanner's Mom »

Yes, thanks so much for sharing this!

Lisa
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