Jun 19, 2006 — WASHINGTON (Reuters) - Stem cells taken from mouse embryos have helped paralyzed rats move again, researchers said on Monday.
The study was the best evidence so far that controversial embryonic stem cells might be used to treat people with spinal cord and other traumatic injuries, the researchers said.
"This study provides a 'recipe' for using stem cells to reconnect the nervous system," Dr. Douglas Kerr of The Johns Hopkins University School of Medicine said in a statement.
"It raises the notion that we can eventually achieve this in humans, although we have a long way to go … We found that we needed a combination of all of the treatments in order to restore function."
Kerr and colleagues used a soup of compounds called growth factors to cause stem cells from the mouse embryos to develop into a type of nerve cell called a motor neuron.
Writing in the Annals of Neurology, they said the transplanted cells, combined with the right mix of compounds, helped paralyzed rats regrow some of their nerve cells and use their hind legs.
"This work is a remarkable advance that can help us understand how stem cells might be used to treat injuries and disease and begin to fulfill their great promise," said Dr. Elias Zerhouni, director of the National Institutes of Health, which funded the study.
more...... http://abcnews.go.com/US/wireStory?id=2095585
This is what I need; I need a few motor neurons. - Why isn’t more being done with respect to studies like this when we have seen several promising animal studies using such cells, including this study? What is holding up this research?
Here is more:
Video of mouse;
http://hopkinsneuro.org/tm/edu_embryonic_win.cfm
Video - Rewiring the Nervous System to Restore Movement by Dr. Douglas Kerr and Dr. Adam Caplin;
http://hopkinsneuro.org/restore/kerr-windows.cfm
Profile Dr. Kerr;
http://hopkinsneuro.org/tm/doc.cfm?i=21
Stem cells regrow damaged nerves in rats: study
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Christopher
- Posts: 845
- Joined: Wed Jun 18, 2003 10:09 pm
- Injury Description, Date, extent, surgical intervention etc: Date of Injury: 12/15/02
Level of Injury:
-dominant side C5, C6, & C7 avulsed. C8 & T1 stretched & crushed
BPI Related Surgeries:
-2 Intercostal nerves grafted to Biceps muscle,
-Free-Gracilis muscle transfer to Biceps Region innervated with 2 Intercostal nerves grafts.
-2 Sural nerves harvested from both Calves for nerve grafting.
-Partial Ulnar nerve grafted to Long Triceps.
-Uninjured C7 Hemi-Contralateral cross-over to Deltoid muscle.
-Wrist flexor tendon transfer to middle, ring, & pinky finger extensors.
Surgical medical facility:
Brachial Plexus Clinic at The Mayo Clinic, Rochester MN
(all surgeries successful)
"Do what you can, with what you have, where you are."
~Theodore Roosevelt - Location: Los Angeles, California USA
-
Christopher
- Posts: 845
- Joined: Wed Jun 18, 2003 10:09 pm
- Injury Description, Date, extent, surgical intervention etc: Date of Injury: 12/15/02
Level of Injury:
-dominant side C5, C6, & C7 avulsed. C8 & T1 stretched & crushed
BPI Related Surgeries:
-2 Intercostal nerves grafted to Biceps muscle,
-Free-Gracilis muscle transfer to Biceps Region innervated with 2 Intercostal nerves grafts.
-2 Sural nerves harvested from both Calves for nerve grafting.
-Partial Ulnar nerve grafted to Long Triceps.
-Uninjured C7 Hemi-Contralateral cross-over to Deltoid muscle.
-Wrist flexor tendon transfer to middle, ring, & pinky finger extensors.
Surgical medical facility:
Brachial Plexus Clinic at The Mayo Clinic, Rochester MN
(all surgeries successful)
"Do what you can, with what you have, where you are."
~Theodore Roosevelt - Location: Los Angeles, California USA
-
Christopher
- Posts: 845
- Joined: Wed Jun 18, 2003 10:09 pm
- Injury Description, Date, extent, surgical intervention etc: Date of Injury: 12/15/02
Level of Injury:
-dominant side C5, C6, & C7 avulsed. C8 & T1 stretched & crushed
BPI Related Surgeries:
-2 Intercostal nerves grafted to Biceps muscle,
-Free-Gracilis muscle transfer to Biceps Region innervated with 2 Intercostal nerves grafts.
-2 Sural nerves harvested from both Calves for nerve grafting.
-Partial Ulnar nerve grafted to Long Triceps.
-Uninjured C7 Hemi-Contralateral cross-over to Deltoid muscle.
-Wrist flexor tendon transfer to middle, ring, & pinky finger extensors.
Surgical medical facility:
Brachial Plexus Clinic at The Mayo Clinic, Rochester MN
(all surgeries successful)
"Do what you can, with what you have, where you are."
~Theodore Roosevelt - Location: Los Angeles, California USA
Re: Stem cells regrow damaged nerves in rats: study
ABC News video coverage on spinal cord injured rat dancing the forbidden dance the "Lambada"...
http://www.cbsnews.com/sections/i_video ... d=1736310n
http://www.cbsnews.com/sections/i_video ... d=1736310n
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Christopher
- Posts: 845
- Joined: Wed Jun 18, 2003 10:09 pm
- Injury Description, Date, extent, surgical intervention etc: Date of Injury: 12/15/02
Level of Injury:
-dominant side C5, C6, & C7 avulsed. C8 & T1 stretched & crushed
BPI Related Surgeries:
-2 Intercostal nerves grafted to Biceps muscle,
-Free-Gracilis muscle transfer to Biceps Region innervated with 2 Intercostal nerves grafts.
-2 Sural nerves harvested from both Calves for nerve grafting.
-Partial Ulnar nerve grafted to Long Triceps.
-Uninjured C7 Hemi-Contralateral cross-over to Deltoid muscle.
-Wrist flexor tendon transfer to middle, ring, & pinky finger extensors.
Surgical medical facility:
Brachial Plexus Clinic at The Mayo Clinic, Rochester MN
(all surgeries successful)
"Do what you can, with what you have, where you are."
~Theodore Roosevelt - Location: Los Angeles, California USA
Re: Stem cells regrow damaged nerves in rats: study
woops CBS news, not ABC.
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catchatrain
- Posts: 49
- Joined: Sat Mar 11, 2006 2:33 pm
Re: Stem cells regrow damaged nerves in rats: study
Watched it last night on the telly.Was flipping thru the channels and there it was.It is great to see that in the future there will be more options, hope and better recovery for the people to follow.Sad that it is not here yet. Make's me understand the need for research that some may see as contriversial......Marshall
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admin
- Site Admin
- Posts: 19873
- Joined: Mon Nov 16, 2009 9:59 pm
Re: Stem cells regrow damaged nerves in rats: study
Christopher,
Thanks for the recent article on stem cells. I, too would like to know what the hold up is? I'm afraid it might be the religious segment not wanting to use emryonic cells. WHO CARES IF IT GIVES MY SON BACK THE USE OF HIS ARM. What is wrong with people???? This affliction can be reversed. I wish Christopher Reeves was still alive. Maybe then more would happen. I did ask the doctors at the Mayo clinic about stem cell research and they poo pooed the idea. Said it wouldn't work. How do they know for sure??????????
Franks Mom
Thanks for the recent article on stem cells. I, too would like to know what the hold up is? I'm afraid it might be the religious segment not wanting to use emryonic cells. WHO CARES IF IT GIVES MY SON BACK THE USE OF HIS ARM. What is wrong with people???? This affliction can be reversed. I wish Christopher Reeves was still alive. Maybe then more would happen. I did ask the doctors at the Mayo clinic about stem cell research and they poo pooed the idea. Said it wouldn't work. How do they know for sure??????????
Franks Mom